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Scientific Research

Macafem’s effectiveness and safety has been supported by:

  • More than 15+ years of scientific research
  • Performed in vitro and in vivo, including clinical trials
  • Conducted in the US, UK and other countries around the world
  • Led by scientists at numerous research institutes and universities
  • Published in renowned peer-reviewed, medical journals
macafem research Takara Clinic

In a recent 2019 clinical trial, researchers studied the effects of Macafem’s main ingredient on reproductive hormone levels in perimenopausal women. They found that 8 weeks of supplementation significantly improved estrogen levels. Women also reported a reduction of insomnia, one of the most notorious menopause symptoms. Additionally, no serious adverse reactions were reported, vouching for Macafem’s safety and efficacy. The results of this trial were published in the reputable, peer-reviewed International Journal of Biomedical Sciences. [1]

Tags: hormonal imbalance, menopause symptoms, insomnia


macafem research GGonzales MD

A 2014 comprehensive review of 80+ scientific studies published in the last 15 years has shown that Macafem’s main ingredient, Lepidium meyenii, possesses hormone-balancing properties. These findings support Macafem’s use as a go-to natural supplement to relieve numerous hormone-related ailments such as the symptoms of menopause or PMS, by naturally increasing the body’s estrogen and progesterone production. This complete ethnopharmacological study was carried out by a renowned Peruvian scientist, Gustavo F. Gonzales, MD together with a team of top scientists. [2]

Tags: hormonal imbalance, menopause symptoms, PMS


macafem research CGonzales Arimborgo

In a 2016 clinical trial involving 175 participants and held by one of the most reputable scientific institutions of South America, researchers observed significant improvements in sexual desire and function after a 12-week supplementation of Macafem’s L. meyenii, which might be particularly beneficial for menopausal women suffering from loss of libido. The participants have also reported positive changes in their energy, endurance levels, and overall outlook on life, which is a crucial finding for those battling menopausal fatigue and mood swings. This research was conducted by a team of researchers at the Peruvian University Cayetano Heredia and published by the Swiss medical journal, Pharmaceuticals. [3]

Tags: loss of libido, fatigue, loss of energy, mood swings


macafem research Christina Dorning

A 2015 clinical trial,conducted through the Depression Clinical and Research Program at the Massachusetts General Hospital, has found L. meyennii, Macafem’s main constituent, a safe and effective treatment for antidepressant-induced sexual dysfunction in pre- and postmenopausal women. Participants reported notable improvements in sexual function, including higher libido and overall satisfaction, positioning Macafem as a suitable herbal supplement for menopause symptoms. The findings of this 12-week clinical trial were published in the renowned Evidence-Based Complementary and Alternative Medicine.[4]

Tags: loss of libido, depression, menopause symptoms


macafem research Yongzhong Zhang 2

A group of scientists from Wuhan University of Science and Technology in China conducted a 12-week in vivo study in 2014 and found strong scientific evidence in favor of medicinal properties of Macafem’s main ingredient. Thanks to its chemical composition, Macafem can be beneficial for menopausal women in regulating female hormonal activity, particularly of estrogen and progesterone, and alleviating notorious symptoms of menopause. The results of this research were featured in the Indian Journal of Pharmacology, an official publication of the Indian Pharmacological Society. [5]

Tags: hormonal imbalance, menopause symptoms, PMS


macafem research LStojanovska PhD

Researchers at the Australian Victoria University have found scientific evidence that Macafem’s main component can improve sexual dysfunction among postmenopausal women, whether it be lack of sexual desire or vaginal dryness. Moreover, it appeared to relieve anxiety and depression, which confirms that Macafem can be used to treat a wide array of postmenopausal symptoms. The results of this 2008 study were published in the New York-based Menopause, the official Journal of the North American Menopause Society. [6]

Tags: loss of libido, vaginal dryness, anxiety, depression


macafem research Yongzhong Zhang

In 2006, the Journal of Ethnopharmacology, which specializes in scientific research on medicinal properties of plants, has published a study, which shows that Macafem’s L. meyenii can prevent loss of bone mass. This scientific discovery is particularly useful for women during the menopausal transition as it marks Macafem an effective option for the prevention of osteoporosis. This 28-week, in vivo research was conducted by a team of Chinese scientists led by Yongzhong Zhang. [7]

Tags: bone loss, osteoporosis


In the last two decades, over 100 scientific studies on Macafem’s active ingredient have been published around the world. The majority of them independently concluded that it efficiently balances hormones during menopause.These findings position Macafem as an excellent supplement -in terms of efficacy and safety- for relieving hormone-related ailments during perimenopause, menopause, and postmenopause and supporting daily functions throughout a woman’s life.

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